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Owing to intrinsic limitations of network meta-analysis, we avoided to analyze the effects of these drugs in several subgroupse.g., as stratified by age or the presence of CV disease or type 2 diabetesto avoid type 1 error due to the many subgroup analyses

The meta-analysis of the ELIXA, LEADER, SUSTAIN-6, EXSCEL, Harmony, PIONEER 6, REWIND and AMPLITUDE-O trials shows that the extent of HbA 1c reduction may serve as a proxy for the renal benefits of GLP-1RA therapy

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Reconstitution and Storage Considerations Both MOTS-c and 5-Amino-1MQ are supplied as lyophilised powders requiring reconstitution with bacteriostatic water before administration